Prof. Dr. med. dent. Florian Just Wegehaupt
Head Division of Preventive Dentistry and Oral Epidemiology
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Research Interests
Tooth wear is mainly caused by caries and erosion. Erosions are defined as acid induced tooth wear without involvement of bacteria. Central to these processes is the dissolution of hydroxyapatite minerals of the teeth. Aim of our research is to understand the basic processes causing these kinds of tooth wear. Furthermore, we are investigating and developing new preventive approaches to prevent these acid induced tooth damages. These preventive approaches are focusing on the tooth wear causing acids and the dental hard tissues itself.
Selected publications
Wegehaupt FJ, Buchalla W, Sener B, Attin T, Schmidlin PR. (2013)
Cerium
Chloride Reduces Enamel Lesion Initiation and Progression in vitro.
Caries Res. 2013;48(1):45-50
Wegehaupt FJ, Tauböck TT, Sener B, Attin T. (2012)
Long-term
protective effect of surface sealants against erosive wear by intrinsic and
extrinsic acids.
J Dent. 2012 May;40(5):416-22
Wegehaupt FJ, Sener B, Attin T, Schmidlin PR. (2011)
Anti-erosive
potential of amine fluoride, cerium chloride and laser irradiation application
on dentine.
Arch Oral Biol. 2011;56(12):1541-7
Wegehaupt F, Günthart N, Sener B, Attin T. (2011)
Prevention
of erosive/abrasive enamel wear due to orange juice modified with dietary
supplements.
Oral Dis. 2011;17(5):508-14
Wegehaupt FJ, Attin T. (2010)
The
role of fluoride and casein phosphopeptide/amorphous calcium phosphate in the
prevention of erosive/abrasive wear in an in vitro model using hydrochloric
acid.
Caries Res. 2010;44(4):358-63
Wegehaupt FJ, Solt B, Sener B, Wiegand A, Schmidlin PR, Attin T. (2009)
Influence
of fluoride concentration and ethanol pre-treatment on the reduction of the
acid susceptibility of enamel.
Arch Oral Biol. 2009 Sep;54(9):823-9
Links
Publications in ZORA (Zurich Open Repository and Archive)
ZORA Publication List
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Publications
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Abrasion of eroded and sound enamel by a dentifrice containing diamond abrasive particles. Swiss Dental Journal, 127(7-8):634-639.
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Anti-erosive effect of a self-assembling peptide gel. Swiss Dental Journal, 127(10):857-864.
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Influence of Different Pretreatments on the Microtensile Bond Strength to Eroded Dentin. Journal of Adhesive Dentistry, 19(2):147-155.
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Influence of Shortened Light-curing Duration on the Potential of Resin-based Surface Sealants to Prevent Erosion. Oral Health & Preventive Dentistry, 15(1):79-87.
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Remineralisation initialer Zahnhartsubstanzdefekte durch Fluoride und CPP-ACP?. Oralprophylaxe und Kinderzahnheilkunde, 39(1):38-44.
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Repair restorations: Questionnaire survey among dentists in the Canton of Zurich, Switzerland. Swiss Dental Journal, 127(4):300-311.
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Etiology and pathogenesis of dental erosion. Quintessence International, 47(4):275-278.
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Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment. In: Maglaveras, Nicos; Gizeli, Electra. pHealth 2016. Amsterdam: I O S Press, 61-66.
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Erosive potential of vitamin and vitamin+mineral effervescent tablets. Swiss Dental Journal, 126(5):457-465.
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Rekonstruktion erosiver Zahnhartsubstanzdefekte mit Komposit. Die Quintessenz, 66(9):1055-1069.
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Eignung von Oberflächenversieglern und Dentinadhäsiven zum Schutz vor erosivem Zahnhartsubstanzverlust. Die Quintessenz, 66(9):1051-1054.
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Ätiologie und Pathogenese erosiver Zahnhartsubstanzdefekte. Die Quintessenz, 66(9):1013-1017.
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Influence of proximal box elevation on the marginal quality and fracture behavior of root-filled molars restored with CAD/CAM ceramic or composite onlays. Clinical Oral Investigations, 19(5):1021-1028.
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Prevention of erosive tooth wear by surface sealants. 2014, University of Zurich, Medizinische Fakultät.
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Methods for assessment of dental erosion. In: Lussi, A; Ganss, C. Erosive Tooth Wear (From Diagnosis to Therapy). Basel: Karger, 123-142.
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Stability of two resin combinations used as sealants against toothbrush abrasion and acid challenge in vitro. Acta Odontologica Scandinavica, 72(8):825-830.
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Influence of The relative enamel abrasivity (REA) of toothpastes on the uptake of KOH-soluble and structurally bound fluoride. Oral Health & Preventive Dentistry, 13(4):349-355.
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Influence of light-curing mode on the cytotoxicity of resin-based surface sealants. BMC Oral Health, 14:48.
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Marginal adaptation of ceramic and composite inlays in minimally invasive mod cavities. Clinical Oral Investigations, 18(2):579-587.
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Cerium chloride reduces enamel lesion initiation and progression in vitro. Caries Research, 48(1):45-50.
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Impact of erosive conditions on tooth-colored restorative materials. Dental Materials, 30(1):43-49.
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Influence of a proximal margin elevation technique on marginal adaptation of ceramic inlays. Acta Odontologica Scandinavica, 71(2):317-324.
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Comparison between different flow application techniques: SDR vs flowable composite. Journal of Adhesive Dentistry, 15(2):115-121.
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Influence of prophylaxis paste treatment on the abrasive wear of surface sealants. Acta Odontologica Scandinavica, 71(3-4):744-750.
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Caries infiltrant combined with conventional adhesives for sealing sound enamel in vitro. Angle Orthodontist, 83(5):858-863.
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Effect of a low-viscosity adhesive resin on the adhesion of metal brackets to enamel etched with hydrochloric or phosphoric acid combined with conventional adhesives. Journal of Adhesive Dentistry, 15(6):575-581.
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How to re-seal previously sealed dentin. American Journal of Dentistry, 26(3):161-165.
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Durability of the anti-erosive effect of surfaces sealants under erosive abrasive conditions. Acta Odontologica Scandinavica, 71(5):1188-1194.
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Impact of laminar flow velocity of different acids on enamel calcium loss. Clinical Oral Investigations, 17(2):595-600.
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Effect of cerium chloride application on fibroblast and osteoblast proliferation and differentiation. Archives of Oral Biology, 57(7):892-897.
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Influence of light-curing mode on the erosion preventive effect of three different resin-based surface sealants. International Journal of Dentistry, 2012:874359.
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The effects of internal tooth bleaching regimens on composite-to-composite bond strength. Journal of the American Dental Association, 143(12):1324-1331.
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Retention of KOH-soluble fluoride formed after application of a SnCl(2)/AmF/NaF containing mouth rinse under erosive conditions. Acta odontologica Scandinavica, 70(4):272-278.
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Long-term protective effect of surface sealants against erosive wear by intrinsic and extrinsic acids. Journal of dentistry, 40(5):416-422.
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Influence of extra- and intra-oral application of CPP-ACP and fluoride on re-hardening of eroded enamel. Acta Odontologica Scandinavica, 70(3):177-183.
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Anti-erosive potential of amine fluoride, cerium chloride and laser irradiation application on dentine. Archives of Oral Biology, 56(12):1541-1547.
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A first study on the usefulness of matrix metalloproteinase 9 from dentinal fluid to indicate pulp inflammation. Journal of Endodontics, 37(1):17-20.
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Effect of sodium hypochlorite contamination on microhardness of dental core build-up materials. Dental Materials Journal, 29(4):469-474.
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Application of cerium chloride to improve the acid resistance of dentine. Archives of Oral Biology, 55(6):441-446.
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Erosion-inhibiting potential of a stannous chloride-containing fluoride solution under acid flow conditions in vitro. Archives of Oral Biology, 55(9):702-705.
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Is bovine dentine an appropriate substitute in abrasion studies. Clinical Oral Investigations, 14(2):201-205.
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Erosion and abrasion of tooth-colored restorative materials and human enamel. Journal of Dentistry, 37(12):913-922.
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Influence of fluoride concentration and ethanol pre-treatment on the reduction of the acid susceptibility of enamel. Archives of Oral Biology, 54(9):823-829.
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Influence of two different fluoride compounds and an in vitro pellicle on the amount of KOH-soluble fluoride and its retention after toothbrushing. Acta Odontologica Scandinavica, 67(6):355-359.